Project 4 - Andriy Khobta

Co-transcriptional repair and transcriptional bypass of bulky DNA adducts

The goal of this project is to understand the consequences of DNA lesions within a transcribed gene for the activity of the affected gene. To this end, we will incorporate a range of physiologically relevant DNA adducts at selected positions into a transcription template and investigate the efficiencies and accuracies of transcriptional bypass of these lesions in cells. In addition, we will address the modes of recognition of structurally distinct DNA lesions in transcribed DNA in order to identify the determinants for detection and removal of damaged nucleotides by the two major branches of the human nucleotide excision repair pathway.

Contact

Project 4 - Andriy Khobta

PD Dr Andriy Khobta

University Medical Center Mainz
Institute of Toxicology
Obere Zahlbacher Strasse 67
55131 Mainz

+49-(0)6131-179271
Email

Webpage Khobta lab