Project 17 - Peter Baumann

The mechanism of telomere protection by shelterin proteins

In this project, we propose to investigate the mechanisms that distinguish chromosome ends from DNA double-strand breaks. We will employ genetic and biochemical approaches to identify the factors that interact with the telomere protein Rap1 in fission yeast and gain a better understanding of how non-homologous end-joining is normally prevented at telomeres. In parallel, we will analyse the composition of mammalian repair complexes at telomeric and non-telomeric DNA ends and elucidate the role of the shelterin component TRF2 in the inhibition of the end-joining pathway. Finally, we will address the impact of nutrient status on telomere stability.

Contact

Project 17 - Peter Baumann

Prof. Dr Peter Baumann

Johannes Gutenberg-University Mainz & Institute of Molecular Biology (IMB)
Ackermannweg 4
55128 Mainz

+49-(0)6131-21422
Email

Webpage Baumann lab