Project 13 - Vassilis Roukos & Kathi Zarnack

Sources and consequences of intrinsic genomic instability across human cell types

This project aims to uncover how the influences of transcription, DNA topology and replication converge to determine which regions of the genome preferentially break. We will investigate whether intrinsic DNA fragility varies between cell types and how this relates to genomic rearrangements found in cancer. To address this, we include a fully-fledged bioinformatics pillar to combine elaborate genomics approaches with multi-modal data integration, quantitative comparisons and machine learning. Our project thereby provides both experimental and computational tools to study genomic instability and strongly contributes to the enhanced emphasis of the consortium on systems approaches.


Project 13 - Vassilis Roukos & Kathi Zarnack

Dr Vassilis Roukos

Institute of Molecular Biology (IMB)
Ackermannweg 4
55128 Mainz


Webpage Roukos lab
Publications since 2019
Project summary first funding period (2019-2022)


Dr Kathi Zarnack

Buchmann Institute for Molecular Life Sciences
Goethe University Frankfurt
Riedberg Campus
Max-von-Laue-Str. 15
60438 Frankfurt am Main


Webpage Zarnack lab
Publications since 2023