Project 20 - Christof Niehrs

Mechanism and biological function of mammalian DNA Poly-ADP-ribosylation

Poly-ADP-ribosylation (PARylation) is regarded as a widespread protein-specific modification closely associated with the DNA damage response. In contrast, we show that also DNA of mammalian cells is physiologically PARylated. DNA PARylation is a reversible enzymatic process and occurs, in specific, on adenine residues within single stranded DNA. We plan to reveal where in the genome adenine PARylation happens, and intend to study the physiological role of DNA PARylation by PARP enzymes using mouse embryonic stem cells.


Project 20 - Christof Niehrs

Prof. Dr Christof Niehrs

Institute of Molecular Biology (IMB)
Ackermannweg 4
55128 Mainz


Webpage Niehrs lab
Publications since 2019