Project 14 - Alexander Löwer

Quantitative time-resolved analysis of DSB repair in individual living cells

In this project, we propose to investigate the repair of endogenous and induced DNA double-strand breaks during cell cycle progression using quantitative time-resolved analysis of individual living cells. To this end, we will combine live-cell imaging of fluorescent reporter cell lines with computational image processing and statistical analysis. Pharmacological perturbations of repair and signalling pathways will thus allow us to gain mechanistic insight into the consequences of repair pathways choices specifically during cell cycle transitions. We will use the resulting quantitative data to establish mathematical models of the interplay between double-strand break repair and cell cycle progression.

Contact

Project 14 - Alexander Löwer

Prof. Dr Alexander Löwer

Technische Universität Darmstadt
Fachbereich Biologie
Schnittspahnstraße 10
64287 Darmstadt

+49-(0)6151-1628060
Email

Webpage Löwer lab