Publications

Publications

Below please find publications from SFB 1361 projects since 2019.

2021

Liebl MC, Moehlenbrink J, Becker H, Raddatz G, Abdeen SK, Aqeilan RI, Lyko F and Hofmann TG (2021) DAZAP2 acts as specifier of the p53 response to DNA damage. Nucleic Acids Res, doi: 10.1093/nar/gkab084 Link

2020

Rausch C, Weber P, Prorok P, Hörl D, Maiser A, Lehmkuhl A, Chagin VO, Casas-Delucchi CS, Leonhardt H and Cardoso MC (2020) Developmental differences in genome replication program and origin activation. Nucleic Acids Res, doi: 10.1093/nar/gkaa1124 Link

Jansma M and Hopfner K-P (2020) Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs. Prog Biophys Mol Biol, doi: 10.1016/j.pbiomolbio.2020.10.009 Link

Allmann S, Mayer L, Olma J, Kaina B, Hofmann TG, Tomicic MT and Christmann M (2020) Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence. Nucleic Acids Res, doi: 10.1093/nar/gkaa965 Link

Alberge J-B, Magrangeas F, Wagner M, Denié S, Guérin-Charbonnel C, Campion L, Attal M, Avet-Loiseau H, Carell T, Moreau P, Minvielle S and Sérandour AA (2020) DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clin Epigenetics, doi: 10.1186/s13148-020-00953-y Link

Bouwman BAM, Agostini F, Garnerone S, Petrosino G, Gothe HJ, Sayols S, Moor AE, Itzkovitz S, Bienko M, Roukos V and Crosetto N (2020) Genome-wide detection of DNA double-strand breaks by in-suspension BLISS. Nat Protoc, doi: 10.1038/s41596-020-0397-3 Link

Dzulko M, Pons M, Henke A, Schneider G and Krämer OH (2020) The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation. Biochim Biophys Acta - Rev Cancer, doi: 10.1016/j.bbcan.2020.188453 Link

Zilio N and Ulrich HD (2020) Exploring the SSBreakome: genome‐wide mapping of DNA single‐strand breaks by next‐generation sequencing. FEBS J, doi: 10.1111/febs.15568 Link

Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L and Kirchhoff F (2020) Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1. Nat Microbiol, doi: 10.1038/s41564-020-0753-6 Link

Petrosino G, Zilio N, Sriramachandran AM and Ulrich HD (2020) Preparation and Analysis of GLOE-Seq Libraries for Genome-Wide Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions.  STAR Protocols, doi: 10.1016/j.xpro.2020.100076 Link

Spada F, Schiffers S, Kirchner A, Zhang Y, Arista G, Kosmatchev O, Korytiakova E, Rahimoff R, Ebert C and Carell T (2020) Active turnover of genomic methylcytosine in pluripotent cells. Nat Chem Biol, doi: 10.1038/s41589-020-0621-y Link

Rodriguez-Alvarez M, Kim D and Khobta A (2020) EGFP Reporters for Direct and Sensitive Detection of Mutagenic Bypass of DNA Lesions. Biomolecules, doi: 10.3390/biom10060902 Link

Wolf E and Kramer A (2020) Circadian Regulation: From Molecules to Physiology. J Mol Biol, doi: 10.1016/j.jmb.2020.05.004 Link

Vydzhak O, Luke B and Schindler N (2020) Non-coding RNAs at the eukaryotic rDNA locus: RNA-DNA hybrids and beyond. J Mol Biol, doi: 10.1016/j.jmb.2020.05.011 Link

Sriramachandran AM, Petrosino G, Méndez-Lago M, Schäfer AJ, Batista-Nascimento LS, Zilio N and Ulrich HD (2020) Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq. Mol Cell, doi: 10.1016/j.molcel.2020.03.027 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J and Dikic I (2020) Wss1 Promotes Replication Stress Tolerance by Degrading Histones. Cell Rep, doi: 10.1016/j.celrep.2020.02.018 Link

Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C and Van Houten B (2020) Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search. Nat Commun, doi: 10.1038/s41467-020-15168-1 Link

Thumbs P, Ensfelder TT, Hillmeier M, Wagner M, Heiss M, Scheel C, Schön A, Müller M, Michalakis S, Kellner S and Carell T (2020) Synthesis of galactosyl‐queuosine and distribution of hypermodified Q‐nucleosides in mouse tissues. Angew Chemie Int Ed, doi: 10.1002/anie.202002295 Link

Ensminger M and Löbrich M (2020) One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks. Br J Radiol, doi: 10.1259/bjr.20191054 Link

Lowe DJ, Herzog M, Mosler T, Cohen H, Felton S, Beli P, Raj K, Galanty Y and Jackson SP (2020) Chronic irradiation of human cells reduces histone levels and deregulates gene expression. Sci Rep, doi: 10.1038/s41598-020-59163-4 Link

Niehrs C and Luke B (2020) Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-019-0206-3 Link

Kiweler N, Wünsch D, Wirth M, Mahendrarajah N, Schneider G, Stauber RH, Brenner W, Butter F and Krämer OH (2020) Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. J Cancer Res Clin Oncol, doi: 10.1007/s00432-019-03118-4 Link

Schön A, Kaminska E, Schelter F, Ponkkonen E, Korytiaková E, Schiffers S and Carell T (2020) Analysis of an active deformylation mechanism of 5-formyl-deoxycytidine (fdC) in stem cells. Angew Chemie Int Ed, doi: 10.1002/anie.202000414 Link

 

2019

Kellner V and Luke B (2019) Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair. EMBO J, doi: 10.15252/embj.2019102309 Link

Chagin VO, Reinhart B, Becker A, Mortusewicz O, Jost KL, Rapp A, Leonhardt H and Cardoso MC (2019) Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. Nucleus, doi: 10.1080/19491034.2019.1688932 Link

Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019) RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids. Cell Rep, doi: 10.1016/j.celrep.2019.10.108 Link

Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T and Hornung V (2019) TLR8 Is a Sensor of RNase T2 Degradation Products. Cell, doi: 10.1016/j.cell.2019.11.001 Link

Jansma M, Linke-Winnebeck C, Eustermann S, Lammens K, Kostrewa D, Stakyte K, Litz C, Kessler B and Hopfner K-P (2019) Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State. Structure, doi: 10.1016/j.str.2019.10.013 Link

Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. Elife, doi: 10.7554/eLife.49044 Link

Liebl MC and Hofmann TG (2019) Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road. BioEssays, doi: 10.1002/bies.201900127 Link

Beyer M, Romanski A, Mustafa A-HM, Pons M, Büchler I, Vogel A, Pautz A, Sellmer A, Schneider G, Bug G and Krämer OH (2019) HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1. Cancers (Basel), doi: 10.3390/cancers11101436 Link

Käshammer L, Saathoff J-H, Lammens K, Gut F, Bartho J, Alt A, Kessler B and Hopfner K-P (2019) Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. Mol Cell, doi: 10.1016/j.molcel.2019.07.035 Link

Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner E-M, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N and Roukos V (2019) Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations. Mol Cell, doi: 10.1016/j.molcel.2019.05.015 Link

Kitsera N, Rodriguez-Alvarez M, Emmert S, Carell T and Khobta A (2019) Nucleotide excision repair of abasic DNA lesions. Nucleic Acids Res, doi: 10.1093/nar/gkz558 Link

Wildenhof T, Schiffers S, Traube FR, Mayer P and Carell T (2019) Influencing epigenetic information with a hydrolytically stable carbocyclic 5 aza-2’-deoxycytidine. Angew Chemie Int Ed, doi: 10.1002/anie.201904794 Link

Wong RP, García-Rodríguez N, Zilio N, Hanulová M and Ulrich HD (2019) Processing of DNA Polymerase-Blocking Lesions during Genome Replication Is Spatially and Temporally Segregated from Replication Forks. Mol Cell, doi: 10.1016/j.molcel.2019.09.015 Link