Project 8 - Ivan Dikic

Molecular mechanisms of replication stress response

The project aims at elucidating the molecular basis of two critical pathways that ensure tolerance to replication stress. In the first part, we will investigate the mechanism of how a conserved protease, SPRTN, contributes to the resolution of covalent and non-covalent protein-DNA interactions and address whether and how its functions are linked to the early embryonic death of Sprtn-/- mice. In the second part, we will elucidate the role of mammalian WRNIP1 protein in the replication of telomeric DNA. Taken together, these approaches will give insight into the molecular mechanisms that ensure faithful and complete duplication of problematic replication templates.

Contact

Project 8 - Ivan Dikic

Prof. Dr Ivan Dikic

Goethe University Frankfurt
University Hospital Frankfurt
Institute of Biochemistry II
Theodor-Stern-Kai 7 / Building 75
60590 Frankfurt am Main

+49-(0)69-63014546
Email

Webpage Dikic lab