Publications since 2019

2021

Gerstmeier J, Possmayer A-L, Bozkurt S, Hoffmann ME, Dikic I, Herold-Mende C, Burger MC, Münch C, Kögel D and Linder B (2021) Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel), doi: 10.3390/cancers13143577 Link

Valečka J, Camosseto V, McEwan DG, Terawaki S, Liu Z, Strock E, Almeida CR, Su B, Dikic I, Liang Y, Gatti E and Pierre P (2021) RUFY4 exists as two translationally regulated isoforms, that localize to the mitochondrion in activated macrophages. R Soc Open Sci, doi: 10.1098/rsos.202333 Link

Liu Y, Mukherjee R, Bonn F, Colby T, Matic I, Glogger M, Heilemann M and Dikic I (2021) Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection. Cell Death Differ, doi: 10.1038/s41418-021-00830-y Link

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P and Kulathu Y (2021) Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies. PLoS One, doi: 10.1371/journal.pone.0253364 Link

Schaefer L and Dikic I (2021) Autophagy: Instructions from the extracellular matrix. Matrix Biol, doi: 10.1016/j.matbio.2021.06.002 Link

Mukherjee R, Bhattacharya A, Bojkova D, Mehdipour AR, Shin D, Khan KS, Hei-Yin Cheung H, Wong K-B, Ng W, Cinatl J, Geurink PP, van der Heden van Noort GJ, Rajalingam K, Ciesek S, Hummer G and Dikic I (2021) Famotidine inhibits Toll-like receptor 3-mediated inflammatory signaling in SARS-CoV2 infection. J Biol Chem, doi: 10.1016/j.jbc.2021.100925 Link

Linder B, Klein C, Hoffmann ME, Bonn F, Dikic I and Kögel D (2021) BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells. J Cell Biochem, doi: 10.1002/jcb.30073 Link

Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, Rao S, Kwon Y, Lim J, Katakam AK, Kunz RC, Erickson BK, Huang T, Tsai T-H, Vitek O, Reichelt M, Senbabaoglu Y, Mckenzie B, Rohde JR, Dikic I, Kirkpatrick DS and Murthy A (2021) Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response. Elife, doi: 10.7554/eLife.62320 Link

Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, Shah VJ, Polat IH, Langschied F, Prieto-Garcia C, Müller K, Kalousi A, Ebersberger I, Brandts CH, Dikic I and Kaulich M (2021) Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res, doi: 10.1093/nar/gkab309 Link

Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle KB, Münch C, Rajalingam K, Randow F, Choudhary C and Dikic I (2021) SIK2 orchestrates actin-dependent host response upon Salmonella infection. Proc Natl Acad Sci, doi: 10.1073/pnas.2024144118 Link

Lo HS, Hui KPY, Lai H-M, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH-Y, Ng K-C, Ho JCW, Chen YW, Ma B, Cheung PM-H, Shin D, Wang K, Lee M-H, Selisko B, Eydoux C, Guillemot J-C, Canard B, Wu K-P, Liang P-H, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong K-B, Mok CKP, Ko H, Aik WS, Chan MCW and Ng W-L (2021) Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir. ACS Cent Sci, doi: 10.1021/acscentsci.0c01186 Link

Kannt A and Đikić I (2021) Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation. Cell Chem Biol, doi: 10.1016/j.chembiol.2021.04.007 Link

Gubas A and Dikic I (2021) A Guide To… The Regulation Of Selective Autophagy Receptors. FEBS J, doi: 10.1111/febs.15824 Link

Klionsky DJ et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 8:1-382 Link

Gubas A, Karantanou C, Popovic D, Tascher G, Hoffmann ME, Platzek A, Dawe N, Dikic I, Krause DS and McEwan D. (2021) The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways. FEBS Lett, doi: 10.1002/1873-3468.14041 Link

Tiku V, Kofoed EM, Yan D, Kang J, Xu M, Reichelt M, Dikic I and Tan M-W (2021) Outer membrane vesicles containing OmpA induce mitochondrial fragmentation to promote pathogenesis of Acinetobacter baumannii. Sci Rep, doi: 10.1038/s41598-020-79966-9 Link

Wells CI, Al-Ali H, Andrews DM, Asquith CRM, Axtman AD, Dikic I, Ebner D, Ettmayer P, Fischer C, Frederiksen M, Futrell RE, Gray NS, Hatch SB, Knapp S, Lücking U, Michaelides M, Mills CE, Müller S, Owen D, Picado A, Saikatendu KS, Schröder M, Stolz A, Tellechea M, Turunen BJ, Vilar S, Wang J, Zuercher WJ, Willson TM and Drewry DH (2021) The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci, doi: 10.3390/ijms22020566 Link

2020

Shin D, Bhattacharya A, Cheng Y-L, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G and Dikic I (2020) Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. Elife, doi: 10.7554/eLife.58277 Link

van der Heden van Noort G, Kim RQ, Misra M, Alexis G, Tomašković I, Shin D, Schindelin H, Filippov D V., Ovaa H and Dikic I (2020) Development of ADPribosyl ubiquitin analogs to study enzymes involved in Legionella infection. Chem – A Eur J, doi: 10.1002/chem.202004590 Link

Waidmann O, Pleli T, Weigert A, Imelmann E, Kakoschky B, Schmithals C, Döring C, Frank M, Longerich T, Köberle V, Hansmann M-L, Brüne B, Zeuzem S, Piiper A and Dikic I (2020) Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis. Sci Rep, doi: 10.1038/s41598-020-73387-4 Link

CA, Conte I, Dikic I, Mann M, Ballabio A, Sacco F, Grumati P and Settembre C (2020) MiT/TFE factors control ER ‐phagy via transcriptional regulation of FAM134B. EMBO J, doi: 10.15252/embj.2020105696 Link

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dötsch V, Akutsu M and Dikic I (2020) Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. Cell Chem Biol, doi: 10.1016/j.chembiol.2020.07.010 Link

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch K-P, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S and Dikic I (2020) Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature, doi: 10.1038/s41586-020-2601-5 Link

van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC and Filippov D V. (2020) Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. ChemBioChem, doi: 10.1002/cbic.202000230 Link

Putyrski M, Vakhrusheva O, Bonn F, Guntur S, Vorobyov A, Brandts C, Dikic I and Ernst A (2020) Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine. Front Cell Dev Biol, doi: 10.3389/fcell.2020.00208 Link

Tiku V, Tan M-W and Dikic I (2020) Mitochondrial Functions in Infection and Immunity.Trends Cell Biol, doi: 10.1016/j.tcb.2020.01.006 Link

Maddi K, Sam DK, Bonn F, Prgomet S, Tulowetzke E, Akutsu M, Lopez-Mosqueda J and Dikic I (2020) Wss1 Promotes Replication Stress Tolerance by Degrading Histones.Cell Rep, doi: 10.1016/j.celrep.2020.02.018 Link

Hübner CA and Dikic I (2020) ER-phagy and human diseases. Cell Death Differ, doi: 10.1038/s41418-019-0444-0 Link

Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I and Heilemann M (2020) Single-molecule imaging reveals the oligomeric state of functional TNFa-induced plasma membrane TNFR1 clusters in cells.Sci Signal, doi: 10.1126/scisignal.aax5647 Link

2019

Pohl C and Dikic I (2019) Cellular quality control by the ubiquitin-proteasome system and autophagy.Science, doi: 10.1126/science.aax3769 Link

Herhaus L, Bhaskara RM, Lystad AH, Gestal-Mato U, Covarrubias-Pinto A, Bonn F, Simonsen A, Hummer G and Dikic I (2019) TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease. EMBO Rep, doi: 10.15252/embr.201948317 Link

Shin D, Mukherjee R, Liu Y, Gonzalez A, Bonn F, Liu Y, Rogov V V., Heinz M, Stolz A, Hummer G, Dötsch V, Luo Z-Q, Bhogaraju S and Dikic I (2019) Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB. Mol Cell, doi: 10.1016/j.molcel.2019.10.019 Link

Bhogaraju S, Bonn F, Mukherjee R, Adams M, Pfleiderer MM, Galej WP, Matkovic V, Lopez-Mosqueda J, Kalayil S, Shin D and Dikic I (2019) Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin-catalysed glutamylation. Nature, doi: 10.1038/s41586-019-1440-8Link

Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, Fregno I, Raimondi A, Marazza A, Bruno G, Iavazzo M, Intartaglia D, Seczynska M, van Anken E, Conte I, De Matteis MA, Dikic I, Molinari M and Settembre C (2019) A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J, doi: 10.15252/embj.201899847 Link

Huber J, Obata M, Gruber J, Akutsu M, Löhr F, Rogova N, Güntert P, Dikic I, Kirkin V, Komatsu M, Dötsch V and Rogov V V. (2019) An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.Autophagy, doi: 10.1080/15548627.2019.1606637 Link

Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V and Kögel D (2019) Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.Cancers (Basel), doi: 10.3390/cancers11030350 Link

Tiku V and Dikic I (2019) Autophagy without conjugation.Nat Struct Mol Biol, doi: 10.1038/s41594-019-0207-0 Link

Poluzzi C, Nastase MV, Zeng-Brouwers J, Roedig H, Hsieh LTH, Michaelis JB, Buhl EM, Rezende F, Manavski Y, Bleich A, Boor P, Brandes RP, Pfeilschifter J, Stelzer EHK, Münch C, Dikic I, Brandts C, Iozzo R V., Wygrecka M and Schaefer L (2019) Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury.Kidney Int, doi: 10.1016/j.kint.2018.10.037 Link

Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A and Kaulich M (2019) Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife, doi: 10.7554/eLife.42549 Link

Bhaskara RM, Grumati P, Garcia-Pardo J, Kalayil S, Covarrubias-Pinto A, Chen W, Kudryashev M, Dikic I and Hummer G (2019) Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy.Nat Commun, doi: 10.1038/s41467-019-10345-3 Link

Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I and Potente M (2019) Deubiquitinase USP10 regulates notch signaling in the endothelium. Science, doi: 10.1126/science.aat0778 Link

Nguyen D, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I and Brandts CH (2019) Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.Blood, doi: 10.1182/blood-2018-02-833475 Link

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I and Rahighi S (2019) Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol, doi: 10.1016/j.jmb.2019.06.012 Link

Mukherjee R and Dikic I (2019) NIPSNAP Beacons in Mitophagy. Dev Cell, doi: 10.1016/j.devcel.2019.05.008 Link

Juretschke T, Beli P and Dikic I (2019) Quantitative phosphoproteomics of selective autophagy receptors.Methods in Molecular Biology, doi: 10.1007/978-1-4939-8873-0_46 Link

van Wijk SJ, Fulda S, Dikic I and Heilemann M (2019) Visualizing ubiquitination in mammalian cells.EMBO Rep, doi: 10.15252/embr.201846520 Link