Publications since 2019

2022

Arab K and Niehrs C (2022) In Vitro Binding of GADD45A to RNA:DNA Hybrids. In: Aguilera, A., Ruzov, A. (eds) R-Loops . Methods in Molecular Biology, vol 2528. Humana, New York, NY, doi:10.1007/978-1-0716-2477-7_18 Link

He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao C, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, Hébert J, Sauvageau G, Spratte J, Fluhr H, Aust G, Müller‐Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB and Pabst C (2022) CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia. EMBO Mol Med, doi: 10.15252/emmm.202114990 Link

Lee H, Sun R and Niehrs C (2022) Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd. J Biol Chem, doi: 10.1016/j.jbc.2022.101586 Link

2021

Niehrs C (2022) The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation. Dev Biol, doi: 10.1016/j.ydbio.2021.11.006 Link

Kim M, Reinhard C and Niehrs C (2021) A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. Elife, doi: 10.7554/eLife.70885 Link

Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C and Niehrs C (2021) RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia. Cell Rep, doi: 10.1016/j.celrep.2021.109559 Link

Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch‐Bräuninger M, Herbst J, Vidal V, Schedl A, Huttner WB and Niehrs C (2021) Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J, doi: 10.15252/embj.2021108041 Link

Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J and Zarnack K (2021) Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning. Nucleic Acids Res, doi: 10.1093/nar/gkab485 Link

Lehmann J, Thiele S, Baschant U, Rachner TD, Niehrs C, Hofbauer LC and Rauner M (2021) Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss. iScience, doi: 10.1016/j.isci.2021.102224 Link

2020

Lee H, Seidl C, Sun R, Glinka A and Niehrs C (2020) R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun, doi: 10.1038/s41467-020-19373-w Link

Harshuk-Shabso S, Dressler H, Niehrs C, Aamar E and Enshell-Seijffers D (2020) Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock. Nat Commun, doi: 10.1038/s41467-020-18643-x Link

Leismann J, Spagnuolo M, Pradhan M, Wacheul L, Vu MA, Musheev M, Mier P, Andrade‐Navarro MA, Graille M, Niehrs C, Lafontaine DL and Roignant J (2020) The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. EMBO Rep, doi: 10.15252/embr.201949443 Link

Musheev MU, Baumgärtner A, Krebs L and Niehrs C (2020) The origin of genomic N6-methyl-deoxyadenosine in mammalian cells. Nat Chem Biol, doi: 10.1038/s41589-020-0504-2 Link

Niehrs C and Luke B (2020) Regulatory R-loops as facilitators of gene expression and genome stability. Nat Rev Mol Cell Biol, doi: 10.1038/s41580-019-0206-3 Link

Chang L-S, Kim M, Glinka A, Reinhard C and Niehrs C (2020) The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. Elife, doi: 10.7554/eLife.51248 Link

2019

Niehrs C and Calkhoven CF (2019) Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing. Trends Genet, doi: 10.1016/j.tig.2019.11.005 Link

Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C (2019) NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. Elife, doi: 10.7554/eLife.49044 Link

Schüle KM, Leichsenring M, Andreani T, Vastolo V, Mallick M, Musheev MU, Karaulanov E and Niehrs C (2019) GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells.Genes Dev, doi: 10.1101/gad.325696.119 Link

Colditz J, Thiele S, Baschant U, Garbe AI, Niehrs C, Hofbauer LC and Rauner M (2019) Osteogenic Dkk1 Mediates Glucocorticoid-Induced but Not Arthritis-Induced Bone Loss. J Bone Miner Res, doi: 10.1002/jbmr.3702 Link

Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M, Guggenhuber S, Brandes C, Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C and Lutz B (2019)  Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNA s . EMBO Rep, doi: 10.15252/embr.201846022 Link

Tsourdi E, Colditz J, Lademann F, Rijntjes E, Köhrle J, Niehrs C, Hofbauer LC and Rauner M (2019) The Role of Dickkopf-1 in Thyroid Hormone-Induced Changes of Bone Remodeling in Male Mice.Endocrinology, doi: 10.1210/en.2018-00998 Link

Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I and Niehrs C (2019) GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet, doi: 10.1038/s41588-018-0306-6 Link