Publications since 2019


Fahrer J and Christmann M (2023) DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways. Int J Mol Sci, doi: 10.3390/ijms24054684 Link


Carlsson MJ, Vollmer AS, Demuth P, Heylmann D, Reich D, Quarz C, Rasenberger B, Nikolova T, Hofmann TG, Christmann M, Fuhlbrueck JA, Stegmüller S, Richling E, Cartus AT and Fahrer J (2022) p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol. Cell Death Dis, doi: 10.1038/s41419-022-05446-9 Link

Behnke A, Mack M, Fieres J, Christmann M, Bürkle A, Moreno-Villanueva M and Kolassa I-T (2022) Expression of DNA repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder, doi: 10.1038/s41598-022-22001-w Link

Beltzig L, Christmann M and Kaina B (2022) Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics. Cells,doi: 10.3390/cells11162588 Link

Vilar JB, Christmann M and Tomicic MT (2022) Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?Cancers (Basel), doi: 10.3390/cancers14102416 Link

Beltzig L, Schwarzenbach C, Leukel P, Frauenknecht KBM, Sommer C, Tancredi A, Hegi ME, Christmann M and Kaina B (2022) Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells. Cancers (Basel), doi: 10.3390/cancers14092233 Link


Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M and Fahrer J (2021) The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. Mol Cancer Ther, doi: 10.1158/1535-7163.MCT-21-0393 Link

Beyer M, Henninger SJ, Haehnel PS, Mustafa A-HM, Gurdal E, Schubert B, Christmann M, Sellmer A, Mahboobi S, Drube S, Sippl W, Kindler T and Krämer OH (2021) Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells. Cell Chem Biol, doi: 10.1016/j.chembiol.2021.10.011 Link

Schwarzenbach C, Tatsch L, Brandstetter Vilar J, Rasenberger B, Beltzig L, Kaina B, Tomicic MT and Christmann M (2021) Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment. Cancers (Basel), doi: 10.3390/cancers13143585 Link

Jiso A, Demuth P, Bachowsky M, Haas M, Seiwert N, Heylmann D, Rasenberger B, Christmann M, Dietrich L, Brunner T, Riyanti, Schäberle TF, Plubrukarn A and Fahrer J (2021) Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal Cancer. Cancers (Basel), doi: 10.3390/cancers13133282 Link

Kostka T, Empl MT, Seiwert N, Geisen SM, Hoffmann P, Adam J, Seeger B, Shay JW, Christmann M, Sturla SJ, Fahrer J and Steinberg P (2021) Repair of O 6-carboxymethylguanine adducts by O 6-methylguanine-DNA methyltransferase in human colon epithelial cells. Carcinogenesis, doi: 10.1093/carcin/bgab049 Link

Reich TR, Schwarzenbach C, Vilar JB, Unger S, Mühlhäusler F, Nikolova T, Poplawski A, Baymaz HI, Beli P, Christmann M and Tomicic MT (2021) Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination. Cell Mol Life Sci, doi: 10.1007/s00018-021-03864-0 Link

Tomicic MT, Krämer F, Nguyen A, Schwarzenbach C and Christmann M (2021) Oxaliplatin-induced senescence in colorectal cancer cells depends on P14ARF-mediated sustained p53 activation. Cancers (Basel), doi: 10.3390/cancers13092019 Link


Tomicic MT, Steigerwald C, Rasenberger B, Brozovic A and Christmann M (2019) Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6. Arch Toxicol, doi: 10.1007/s00204-019-02513-7 Link

Neitzel C, Seiwert N, Göder A, Diehl E, Weber C, Nagel G, Stroh S, Rasenberger B, Christmann M and Fahrer J (2019) Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation. Cells, doi: 10.3390/cells8080794 Link

Kaina B and Christmann M (2019) DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.DNA Repair (Amst), doi: 10.1016/j.dnarep.2019.04.007 Link

Aasland D, Gotzinger L, Hauck L, Berte N, Meyer J, Effenberger M, Schneider S, Reuber EE, Roos WP, Tomicic MT, Kaina B and Christmann M (2019) Temozolomide induces senescence and repression of DNA repair pathways in glioblastoma cells via activation of ATR–Chk1, p21, and NF-kB. Cancer Res, doi: 10.1158/0008-5472.CAN-18-1733 Link