Publications since 2019


Węgrzyn E, Mejdrová I, Müller F, Nainytė M, Escobar L and Carell T (2024) RNA‐Templated Peptide Bond Formation Promotes L‐Homochirality. Angew Chemie Int Ed, doi: 10.1002/anie.202319235 Link


Helm M, Bohnsack MT, Carell T, Dalpke A, Entian K-D, Ehrenhofer-Murray A, Ficner R, Hammann C, Höbartner C, Jäschke A, Jeltsch A, Kaiser S, Klassen R, Leidel SA, Marx A, Mörl M, Meier JC, Meister G, Rentmeister A, Rodnina M, Roignant J-Y, Schaffrath R, Stadler P and Stafforst T (2023) Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications. ACS Chem Biol, doi: 10.1021/acschembio.3c00586 Link

Pichler A, Hillmeier M, Heiss M, Peev E, Xefteris S, Steigenberger B, Thoma I, Müller M, Borsò M, Imhof A and Carell T (2023) Synthesis and Structure Elucidation of Glutamyl-Queuosine. J Am Chem Soc, doi: 10.1021/jacs.3c10075 Link

Karousi P, Samiotaki M, Makridakis M, Zoidakis J, Sideris DC, Scorilas A, Carell T and Kontos CK (2023) 3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways. Funct Integr Genomics, doi: 10.1007/s10142-023-01272-0 Link

Schönegger ES, Crisp A, Radukic M, Burmester J, Frischmuth T and Carell T (2023) Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click‐Reactive NTP Analogues. ChemBioChem, doi: 10.1002/cbic.202300701 Link

Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A and Niessing D (2023) Human TRMT2A methylates tRNA and contributes to translation fidelity. Nucleic Acids Res, doi: 10.1093/nar/gkad565 Link

Nieborak A, Lukauskas S, Capellades J, Heyn P, Santos GS, Motzler K, Zeigerer A, Bester R, Protzer U, Schelter F, Wagner M, Carell T, Hruscha A, Schmid B, Yanes O and Schneider R (2023) Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis. Mol Metab, doi: 10.1016/j.molmet.2023.101748 Link

Feldmann J, Skaanning MK, Lommel M, Kernmayr T, Mayer P and Carell T (2023) A Unifying Concept for the Prebiotic Formation of RNA Pyrimidine Nucleosides. ChemistryEurope, doi: 10.1002/ceur.202300013 Link

Singer JN, Müller FM, Węgrzyn E, Hölzl C, Hurmiz H, Liu C, Escobar L and Carell T (2023) Loading of Amino Acids onto RNA in a Putative RNA‐Peptide World. Angew Chemie Int Ed, doi: 10.1002/anie.202302360 Link

Kuhl N, Linder A, Philipp N, Nixdorf D, Fischer H, Veth S, Kuut G, Xu TT, Theurich S, Carell T, Subklewe M and Hornung V (2023)  STING agonism turns human T cells into interferon‐producing cells but impedes their functionality . EMBO Rep, doi: 10.15252/embr.202255536 Link


Searle B, Müller M, Carell T and Kellett A (2022) Third Generation Sequencing of Epigenetic DNA.Angew Chem Int Ed Engl, doi: 10.1002/anie.202215704 Link

Montiel L, Spada F, Crisp A, Serdjukow S, Carell T and Frischmuth T (2022) Divergent Synthesis of Ultrabright and Dendritic Xanthenes for Enhanced Click Chemistry‐Based Bioimaging. Chem – A Eur J, doi: 10.1002/chem.202202633 Link

Patel BI, Heiss M, Samel-Pommerencke A, Carell T and Ehrenhofer-Murray AE (2022) Queuosine salvage in fission yeast by Qng1-mediated hydrolysis to queuine. Biochem Biophys Res Commun,doi: 10.1016/j.bbrc.2022.07.104 Link

Schönegger ES, Crisp A, Müller M, Fertl J, Serdjukow S, Croce S, Kollaschinski M, Carell T and Frischmuth T (2022) Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing. Bioconjug Chem, doi: 10.1021/acs.bioconjchem.2c00353 Link

Xu F, Crisp A, Schinkel T, Dubini RCA, Hübner S, Becker S, Schelter F, Rovó P and Carell T (2022) Isoxazole Nucleosides as Building Blocks for a Plausible Proto‐RNA. Angew Chemie Int Ed, doi: 10.1002/anie.202211945 Link

Arroyo M, Hastert FD, Zhadan A, Schelter F, Zimbelmann S, Rausch C, Ludwig AK, Carell T and Cardoso MC (2022) Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. Nat Commun, doi: 10.1038/s41467-022-32799-8 Link 

Stazzoni S, Böhmer DFR, Hernichel F, Özdemir D, Pappa A, Drexler D, Bauernfried S, Witte G, Wagner M, Veth S, Hopfner K-P, Hornung V, König LM and Carell T (2022) Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING AgonistsAngewandte Chemie Int Ed, doi: 10.1002/anie.202207175 Link

Traube FR, Stern M, Tölke AJ, Rudelius M, Mejías‐Pérez E, Raddaoui N, Kümmerer BM, Douat C, Streshnev F, Albanese M, Wratil PR, Gärtner Y V., Nainytė M, Giorgio G, Michalakis S, Schneider S, Streeck H, Müller M, Keppler OT and Carell T (2022) Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs. Angew Chemie Int Ed, doi: 10.1002/anie.202204556 Link

Czuppa M, Dhingra A, Zhou Q, Schludi C, König L, Scharf E, Farny D, Dalmia A, Täger J, Castillo-Lizardo M, Katona E, Mori K, Aumer T, Schelter F, Müller M, Carell T, Kalliokoski T, Messinger J, Rizzu P, Heutink P and Edbauer D (2022) Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD. Cell Rep, doi: 10.1016/j.celrep.2022.110913 Link

Dubini RCA, Korytiaková E, Schinkel T, Heinrichs P, Carell T and Rovó P (2022)  1 H NMR Chemical Exchange Techniques Reveal Local and Global Effects of Oxidized Cytosine Derivatives . ACS Phys Chem Au, doi: 10.1021/acsphyschemau.1c00050 Link

Müller F, Escobar L, Xu F, Węgrzyn E, Nainytė M, Amatov T, Chan C, Pichler A and Carell T (2022) A prebiotically plausible scenario of an RNA–peptide world. Nature, doi: 10.1038/s41586-022-04676-3 Link

Traube FR, Brás NF, Roos WP, Sommermann CC, Diehl T, Mayer RJ, Ofial AR, Müller M, Zipse H and Carell T (2022) Epigenetic Anti‐Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue. Chem – A Eur J, doi: 10.1002/chem.202200640 Link

Veth S, Fuchs A, Özdemir D, Dialer C, Drexler DJ, Knechtel F, Witte G, Hopfner K-P, Carell T and Ploetz E (2022) Chemical synthesis of the fluorescent, cyclic dinucleotides cthGAMP. ChemBioChem, doi: 10.1002/cbic.202200005 Link

Panosyan H, Traube FR, Brandmayr C, Wagner M and Carell T (2022) tRNA modification profiles in obligate and moderate thermophilic bacilli. Extremophiles, doi: 10.1007/s00792-022-01258-z Link

Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A and Rossetti G (2022) Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. Comput Struct Biotechnol J, doi: 10.1016/j.csbj.2021.12.029 Link



Hillmeier M, Wagner M, Ensfelder T, Korytiakova E, Thumbs P, Müller M and Carell T (2021) Synthesis and structure elucidation of the human tRNA nucleoside mannosyl-queuosine. Nat Commun, doi: 10.1038/s41467-021-27371-9 Link

Kabaciński P, Romanelli M, Ponkkonen E, Jaiswal VK, Carell T, Garavelli M, Cerullo G and Conti I (2021) Unified Description of Ultrafast Excited State Decay Processes in Epigenetic Deoxycytidine Derivatives. J Phys Chem Lett, doi: 10.1021/acs.jpclett.1c02909 Link

Müller N, Ponkkonen E, Carell T and Khobta A (2021) Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine. Int J Mol Sci, doi: 10.3390/ijms222011025 Link

Kamińska E, Korytiaková E, Reichl A, Müller M and Carell T (2021) Intragenomic decarboxylation of 5‐carboxy‐2’‐deoxycytidine. Angew Chemie Int Ed, doi: 10.1002/anie.202109995 Link

Jütte BB, Krollmann C, Cieslak K, Koerber R-M, Boor P, Graef CM, Bartok E, Wagner M, Carell T, Landsberg J, Aymans P, Wenzel J, Brossart P and Teichmann LL (2021) Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. iScience, doi: 10.1016/j.isci.2021.102833 Link

Traube FR, Özdemir D, Sahin H, Scheel C, Glück AF, Geserich AS, Oganesian S, Kostidis S, Iwan K, Rahimoff R, Giorgio G, Müller M, Spada F, Biel M, Cox J, Giera M, Michalakis S and Carell T (2021) Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons. Nat Commun, doi: 10.1038/s41467-021-24353-9 Link

Swain U, Friedlander G, Sehrawat U, Sarusi-Portuguez A, Rotkopf R, Ebert C, Paz-Elizur T, Dikstein R, Carell T, Geacintov NE and Livneh Z (2021) TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer. Int J Mol Sci, doi: 10.3390/ijms22136957 Link

Schmidl D, Jonasson N, Korytiakova E, Carell T and Daumann L (2021) Biomimetic iron complex achieves TET enzyme reactivity**. Angew Chemie Int Ed, doi: 10.1002/anie.202107277 Link

Runtsch LS, Stadlmeier M, Schön A, Müller M and Carell T (2021) Comparative nucleosomal reactivity of 5‐formyl‐uridine and 5‐formyl‐cytidine. Chem – A Eur J, doi: 10.1002/chem.202102159 Link

Korytiaková E, Kamińska E, Müller M and Carell T (2021) Deformylation of 5‐Formylcytidine in Different Cell Types. Angew Chemie Int Ed, doi: 10.1002/anie.202107089 Link

Traube FR, Schiffers S and Carell T (2021) Quantification of DNA Methylation and Its Oxidized Derivatives Using LC-MS. Doi: 10.1007/978-1-0716-1294-1_6 Link

Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA and West SC (2021) Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors . Science (80- ), doi: 10.1126/science.abb4542 Link

Thilgen C, Wennemers H and Carell T (2021) François Diederich (1952–2020): 40 Years of Organic Chemistry. Angew Chemie Int Ed, doi: 10.1002/anie.202101232 Link

Schelter F, Kirchner A, Traube FR, Müller M, Steglich W and Carell T (2021) 5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks. Chem – A Eur J, doi: 10.1002/chem.202100551 Link


Koch M, Scheel C, Ma H, Yang F, Stadlmeier M, Glück AF, Murenu E, Traube FR, Carell T, Biel M, Ding X-Q and Michalakis S (2020) The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. Int J Mol Sci, doi: 10.3390/ijms22010052 Link

Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanashi M, Bultmann S and Leonhardt H (2020) Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun, doi: 10.1038/s41467-020-19603-1 Link

Alberge J-B, Magrangeas F, Wagner M, Denié S, Guérin-Charbonnel C, Campion L, Attal M, Avet-Loiseau H, Carell T, Moreau P, Minvielle S and Sérandour AA (2020) DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clin Epigenetics, doi: 10.1186/s13148-020-00953-y Link

Spada F, Schiffers S, Kirchner A, Zhang Y, Arista G, Kosmatchev O, Korytiakova E, Rahimoff R, Ebert C and Carell T (2020) Active turnover of genomic methylcytosine in pluripotent cells. Nat Chem Biol, doi: 10.1038/s41589-020-0621-y Link

Carell T, Nainyte M, Müller F, Ganazzoli G, Chan C-Y, Crisp A and Globisch D (2020) Title Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.Chem – A Eur J, doi: 10.1002/chem.202002929 Link

Dubini RCA, Schön A, Müller M, Carell T and Rovó P (2020) Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange. Nucleic Acids Res, doi: 10.1093/nar/gkaa589 Link

Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl E-M, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H and Bultmann S (2020) Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency.Sci Rep, doi: 10.1038/s41598-020-68600-3 Link

Lauria T, Slator C, McKee V, Müller M, Stazzoni S, Crisp AL, Carell T and Kellett A (2020) A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors.Chem – A Eur J, doi: 10.1002/chem.202002860 Link

Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C and Van Houten B (2020) Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search.Nat Commun, doi: 10.1038/s41467-020-15168-1 Link

Thumbs P, Ensfelder TT, Hillmeier M, Wagner M, Heiss M, Scheel C, Schön A, Müller M, Michalakis S, Kellner S and Carell T (2020) Synthesis of galactosyl-queuosine and distribution of hypermodified Q-nucleosides in mouse tissues.Angew Chemie Int Ed, doi: 10.1002/anie.202002295 Link

Raddaoui N, Groce S, Geiger F, Borodavka A, Möckl L, Stazzoni S, Viverge B, Bräuchle C, Frischmuth T, Engelke H and Carell T (2020) Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry. ChemBioChem, doi: 10.1002/cbic.202000081 Link

Croce S, Serdjukow S, Carell T and Frischmuth T (2020) Chemo-Enzymatic Preparation of Functional Click Labelled Messenger RNA.ChemBioChem, doi: 10.1002/cbic.201900718 Link

Schön A, Kaminska E, Schelter F, Ponkkonen E, Korytiaková E, Schiffers S and Carell T (2020) Analysis of an active deformylation mechanism of 5-formyl-deoxycytidine (fdC) in stem cells. Angew Chemie Int Ed, doi: 10.1002/anie.202000414 Link


Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T and Hornung V (2019) TLR8 Is a Sensor of RNase T2 Degradation Products.Cell, doi: 10.1016/j.cell.2019.11.001 Link

Stadlmeier M, Runtsch LS, Streshnev F, Wühr M and Carell T (2019) A Click-chemistry based enrichable cross-linker for structural and protein interaction analysis by mass spectrometry.ChemBioChem, doi: 10.1002/cbic.201900611 Link

Becker S, Feldmann J, Wiedemann S, Okamura H, Schneider C, Iwan K, Crisp A, Rossa M, Amatov T and Carell T (2019) Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, doi: 10.1126/science.aax2747 Link

Okamura H, Crisp A, Hübner S, Becker S, Rovo P and Carell T (2019) proto-Urea-RNA (Wöhler RNA) containing unusually stable urea nucleosides. Angew Chemie Int Ed, doi: 10.1002/anie.201911746 Link

Nainytė M, Amatov T and Carell T (2019) Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA. Chem Commun, doi: 10.1039/C9CC06314E Link

Gontcharov J, Pilles B, Liu L, Carell T, Schreier W and Zinth W (2019) Triplet Induced Lesion Formation at CpT and TpC Sites in DNA. Chem – A Eur J, doi: 10.1002/chem.201903573 Link

Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP and Carell T (2019) A Click-Chemistry Linked 2′3′-cGAMP Analogue. Chem - A Eur J, doi: 10.1002/chem.201805409 Link

Okamura H, Becker S, Tiede N, Wiedemann S, Feldmann J and Carell T (2019) A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions. Chem Commun, doi: 10.1039/c8cc09435g Link

Traube FR, Schiffers S, Iwan K, Kellner S, Spada F, Müller M and Carell T (2019) Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides. Nat Protoc, doi: 10.1038/s41596-018-0094-6 Link

Kitsera N, Rodriguez-Alvarez M, Emmert S, Carell T and Khobta A (2019) Nucleotide excision repair of abasic DNA lesions. Nucleic Acids Res, doi: 10.1093/nar/gkz558 Link

Wildenhof T, Schiffers S, Traube FR, Mayer P and Carell T (2019) Influencing epigenetic information with a hydrolytically stable carbocyclic 5 aza-2’-deoxycytidine. Angew Chemie Int Ed, doi: 10.1002/anie.201904794 Link