Publications since 2019

2021

Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA and West SC (2021) Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA -deficient cells to PARP inhibitors . Science (80- ), doi: 10.1126/science.abb4542 Link

Thilgen C, Wennemers H and Carell T (2021) François Diederich (1952–2020): 40 Years of Organic Chemistry. Angew Chemie Int Ed, doi: 10.1002/anie.202101232 Link

Schelter F, Kirchner A, Traube FR, Müller M, Steglich W and Carell T (2021) 5‐Hydroxymethyl‐, 5‐Formyl‐ and 5‐Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks. Chem – A Eur J, doi: 10.1002/chem.202100551 Link

2020

Koch M, Scheel C, Ma H, Yang F, Stadlmeier M, Glück AF, Murenu E, Traube FR, Carell T, Biel M, Ding X-Q and Michalakis S (2020) The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia. Int J Mol Sci, doi: 10.3390/ijms22010052 Link

Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanashi M, Bultmann S and Leonhardt H (2020) Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun, doi: 10.1038/s41467-020-19603-1 Link

Alberge J-B, Magrangeas F, Wagner M, Denié S, Guérin-Charbonnel C, Campion L, Attal M, Avet-Loiseau H, Carell T, Moreau P, Minvielle S and Sérandour AA (2020) DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clin Epigenetics, doi: 10.1186/s13148-020-00953-y Link

Spada F, Schiffers S, Kirchner A, Zhang Y, Arista G, Kosmatchev O, Korytiakova E, Rahimoff R, Ebert C and Carell T (2020) Active turnover of genomic methylcytosine in pluripotent cells. Nat Chem Biol, doi: 10.1038/s41589-020-0621-y Link

Carell T, Nainyte M, Müller F, Ganazzoli G, Chan C-Y, Crisp A and Globisch D (2020) Title Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.Chem – A Eur J, doi: 10.1002/chem.202002929 Link

Dubini RCA, Schön A, Müller M, Carell T and Rovó P (2020) Impact of 5-formylcytosine on the melting kinetics of DNA by 1H NMR chemical exchange. Nucleic Acids Res, doi: 10.1093/nar/gkaa589 Link

Mulholland CB, Traube FR, Ugur E, Parsa E, Eckl E-M, Schönung M, Modic M, Bartoschek MD, Stolz P, Ryan J, Carell T, Leonhardt H and Bultmann S (2020) Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency.Sci Rep, doi: 10.1038/s41598-020-68600-3 Link

Lauria T, Slator C, McKee V, Müller M, Stazzoni S, Crisp AL, Carell T and Kellett A (2020) A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors.Chem – A Eur J, doi: 10.1002/chem.202002860 Link

Beckwitt EC, Jang S, Carnaval Detweiler I, Kuper J, Sauer F, Simon N, Bretzler J, Watkins SC, Carell T, Kisker C and Van Houten B (2020) Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search.Nat Commun, doi: 10.1038/s41467-020-15168-1 Link

Thumbs P, Ensfelder TT, Hillmeier M, Wagner M, Heiss M, Scheel C, Schön A, Müller M, Michalakis S, Kellner S and Carell T (2020) Synthesis of galactosyl-queuosine and distribution of hypermodified Q-nucleosides in mouse tissues.Angew Chemie Int Ed, doi: 10.1002/anie.202002295 Link

Raddaoui N, Groce S, Geiger F, Borodavka A, Möckl L, Stazzoni S, Viverge B, Bräuchle C, Frischmuth T, Engelke H and Carell T (2020) Super-sensitive multi-fluorophore RNA-FISH for early virus detection and flow-FISH using click chemistry. ChemBioChem, doi: 10.1002/cbic.202000081 Link

Croce S, Serdjukow S, Carell T and Frischmuth T (2020) Chemo-Enzymatic Preparation of Functional Click Labelled Messenger RNA.ChemBioChem, doi: 10.1002/cbic.201900718 Link

Schön A, Kaminska E, Schelter F, Ponkkonen E, Korytiaková E, Schiffers S and Carell T (2020) Analysis of an active deformylation mechanism of 5-formyl-deoxycytidine (fdC) in stem cells. Angew Chemie Int Ed, doi: 10.1002/anie.202000414 Link

2019

Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T and Hornung V (2019) TLR8 Is a Sensor of RNase T2 Degradation Products.Cell, doi: 10.1016/j.cell.2019.11.001 Link

Stadlmeier M, Runtsch LS, Streshnev F, Wühr M and Carell T (2019) A Click-chemistry based enrichable cross-linker for structural and protein interaction analysis by mass spectrometry.ChemBioChem, doi: 10.1002/cbic.201900611 Link

Becker S, Feldmann J, Wiedemann S, Okamura H, Schneider C, Iwan K, Crisp A, Rossa M, Amatov T and Carell T (2019) Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, doi: 10.1126/science.aax2747 Link

Okamura H, Crisp A, Hübner S, Becker S, Rovo P and Carell T (2019) proto-Urea-RNA (Wöhler RNA) containing unusually stable urea nucleosides. Angew Chemie Int Ed, doi: 10.1002/anie.201911746 Link

Nainytė M, Amatov T and Carell T (2019) Synthesis of an acp 3 U phosphoramidite and incorporation of the hypermodified base into RNA. Chem Commun, doi: 10.1039/C9CC06314E Link

Gontcharov J, Pilles B, Liu L, Carell T, Schreier W and Zinth W (2019) Triplet Induced Lesion Formation at CpT and TpC Sites in DNA. Chem – A Eur J, doi: 10.1002/chem.201903573 Link

Dialer CR, Stazzoni S, Drexler DJ, Müller FM, Veth S, Pichler A, Okamura H, Witte G, Hopfner KP and Carell T (2019) A Click-Chemistry Linked 2′3′-cGAMP Analogue. Chem - A Eur J, doi: 10.1002/chem.201805409 Link

Okamura H, Becker S, Tiede N, Wiedemann S, Feldmann J and Carell T (2019) A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions. Chem Commun, doi: 10.1039/c8cc09435g Link

Traube FR, Schiffers S, Iwan K, Kellner S, Spada F, Müller M and Carell T (2019) Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides. Nat Protoc, doi: 10.1038/s41596-018-0094-6 Link

Kitsera N, Rodriguez-Alvarez M, Emmert S, Carell T and Khobta A (2019) Nucleotide excision repair of abasic DNA lesions. Nucleic Acids Res, doi: 10.1093/nar/gkz558 Link

Wildenhof T, Schiffers S, Traube FR, Mayer P and Carell T (2019) Influencing epigenetic information with a hydrolytically stable carbocyclic 5 aza-2’-deoxycytidine. Angew Chemie Int Ed, doi: 10.1002/anie.201904794 Link