New review from the Ulrich lab on daughter-strand gaps in DNA replication


The review describes the factors controlling the emergence of daughter-strand gaps from stalled replication intermediates. It also discusses the benefits and risks of their expansion and repair via translesion synthesis or recombination-mediated template switching, and the mechanisms by which they activate local as well as global replication stress signals. Click here to read more.

Wong RP, Petriukov K and Ulrich HD (2021) Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling. DNA Repair (Amst), doi: 10.1016/j.dnarep.2021.103163 Link