New review from the Hopfner lab on DDR kinases ATM, ATR and DNA-PKcs
Marijke Jansma and Karl-Peter Hopfner have reviewed recent structural analyses of the DNA damage response kinases ATM, ATR and DNA-PKcs and their possible mechanism of (auto)inhibition, activation and substrate recognition. You can read the review here.
Jansma M and Hopfner K-P (2020) Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs. Prog Biophys Mol Biol, doi: 10.1016/j.pbiomolbio.2020.10.009