New review by the Luke lab - "Non-coding RNAs at the eukaryotic rDNA locus: RNA-DNA hybrids and beyond"
In this review, the authors from the Luke lab report about the current knowledge on R-loops and triplexes specifically at the rDNA locus in yeast and human cells and what is known about their role in the regulation of rDNA biology. They discuss the protein regulators of RNA-DNA hybrids at rDNA and speculate on how genomic rNMPs and oxidative lesions might affect them.
The article is part of a special issue of the Journal of Molecular Biology on “Non coding RNAs at telomeres and other repetitive regions of the genome” edited by SFB 1361 members Peter Baumann and Brian Luke.
Please find the full text here.
O. Vydzhak, B. Luke and N. Schindler, Non-coding RNAs at the eukaryotic rDNA locus: RNA-DNA hybrids and beyond, Journal of Molecular Biology (2020), doi.org/10.1016/j.jmb.2020.05.011