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New publication from the Hopfner lab on the molecular basis of human ATM kinase inhibition

In this new publication, the Hopfner lab used cryo-electron microscopy to retrieve a high-resolution structure of the human checkpoint kinase ATM. ATM is a central element in the initiation of the DNA damage response upon DNA double strand breaks. This exciting work can play an important role in characterizing known ATM inhibitors and provides a framework for structure-based drug design. Read the full paper here.

Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, Pehl U, Alt A, van de Logt E and Hopfner KP (2021) Molecular basis of human ATM kinase inhibition. Nat Struct Mol Biol, doi: 10.1038/s41594-021-00654-x Link