New paper published from the collaborative work between the Khobta lab and the Carell lab


This collaboration between the Khobta and Carell lab examined the functions of the epigenetic marks 5-formylcytosine (5-fC) and 5-carboxycytosine (5-caC). By using synthetic analogs of the afore-mentioned epigenetic marks, which are naturally present in DNA, the authors revealed that 5-caC may act as repressory mark to prevent premature activation of promotors undergoing the final stages of DNA demethylation. Read the full paper here.

Müller N, Ponkkonen E, Carell T and Khobta A (2021) Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine. Int J Mol Sci, doi: 10.3390/ijms222011025 Link